At 0 hours after extubation, the incidence of CRBD in group D was reduced to 23%, compared with 74% in group C (p<0.
On the basis of percentages given in Agarwal's study, in our study patients in group C experienced a higher incidence of CRBD (68% at 1 hour after extubation) compared with the expected incidence (58% at 1 hour after extubation) (4).
Based on these facts we hypothesized that dexmedetomidine would reduce the incidence and severity of CRBD through its suppressing effect on the central and peripheral nervous systems.
An indwelling urinary catheter may stimulate the mucous membrane of the urethra and thus initiate the micturition reflex, leading to an urgent need to urinate; this may be one of the key mechanisms in the pathogenesis of CRBD.
However, the incidence and severity of CRBD were significantly reduced in group D at each time point (0, 1, 2, and 6 hours) compared with group C.
dexmedetomidine does not reduce CRBD simply by compromising the patients' ability to perceive discomfort.
We therefore concluded that the effect of dexmedetomidine on hemodynamic stability was acceptable and easily managed, which supports the practicability of our proposal to use dexmedetomidine in preventing CRBD.
We evaluated the effect of dexmedetomidine in preventing or ameliorating CRBD in patients after open upper-middle abdominal surgeries.