sup], Both cAMP-dependent protein kinase A (PKA) and CREB
are activated in the course of spatial learning.
The phosphorylation of ERK1/2 (b) and CREB
(c) peaked at 1 h.
The fact that during periods of nutritional hardship, echinoid larvae up-regulate both CREB
and NFKB (Figs.
Numerosos estudios demuestran que la expresion de genes dependiente de CREB
es necesaria para la formacion y consolidacion de memorias asociativas (Lamprecht, Hazvi & Dudai, 1997; Yin et al.
, encoding or short-term memory, consolidation into long-term memory:
In fact, the increase in BDNF mRNA levels could be linked to the activation of NF-[kappa]B and CREB
The low BDNF levels resulted in reduced BDNF signaling, as evidenced by decreased levels of the phosphorylated forms of CREB
and another regulatory molecule (Pandey et al.
2006), BIC increased phosphorylation of the active site (Ser133) of CREB
En contraste, un estudio reporto que la disminucion de CREB
no repercute sobre el condicionamiento contextual de miedo, pero si sobre el condicionamiento aversivo a sabores (43).
program provides these nonprofit utilities with interest-free loans for financing qualified renewable energy projects.
Long-term potentiation, the Hebb rule, and CREB
protein are associated with the formation of long-term memories.
In humans, changes in CREB
protein expression and phosphorylation have been demonstrated in those committing suicide, and the CREB
1 region has been linked to major depressive disorder," the investigators said.