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CRF1 |
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The compounds being licensed are CRF1 receptor antagonists. The CRF1 receptor subtype largely mediates these effects. The results indicated that selective and potent CRF1 receptor antagonists can be neuroprotective following permanent focal cerebral ischemia and showed that the protection was maintained when treatment was initiated up to one hour after the ischemic insult, confirming the involvement of the CRF1 receptor sub-type in the genesis of ischemic brain damage. |
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