When this happens, CRF1
tells these cells to release chemical substances that can lead to inflammatory and allergic diseases such as irritable bowel syndrome, asthma, life-threatening food allergies and autoimmune disorders such as lupus.
One group of mice was considered "normal" with CRF1
receptors on their mast cells and the other group had cells that lacked CRF1
Mice lacking a functional CRF1
receptor progressively increased their ethanol intake when subjected to repeated stress; this effect seemed to persist throughout their life (Sillaber et al.
It is clear from this study that CRF1
remains a difficult drug target in the drive to improve current therapies for depression," said Kevin Gorman, president and chief executive officer of Neurocrine Biosciences.
The action of CRF is mediated through G-protein--coupled CRF1
receptors in the pituitary and through CRF1
and CRF2 receptors in brain areas such as the extended amygdala (Dautzenberg and Hauger 2002).
systemically) produced similar effects, suggesting that withdrawal-related anxiety is mediated by CRF1
receptors (Breese et al.
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF 1 receptor antagonist antalarmin and by CRF1
Gene-environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1
Moreover, levels of CRF1
receptors in dependent animals are increased following alcohol withdrawal, and CRF1
antagonists have been shown to reduce alcohol self-administration (for a review, see Heilig and Koob 2007).
Pipeline candidates fall under major therapeutic classes such as Serotonin receptor targets, Guanylate cyclase type C receptor agonist, NK receptor targets, CRF1
single nucleotide polymorphisms [SNPs]) in the gene encoding CRF1
were associated with alcohol consumption and a lifetime prevalence of drunkenness in two independent samples (Treutlein et al.
Janssen Collaboration Also Moves Forward With CRF1