CRF1Corticotropin-Releasing Factor 1
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When this happens, CRF1 tells these cells to release chemical substances that can lead to inflammatory and allergic diseases such as irritable bowel syndrome, asthma, life-threatening food allergies and autoimmune disorders such as lupus.
One group of mice was considered "normal" with CRF1 receptors on their mast cells and the other group had cells that lacked CRF1.
Mice lacking a functional CRF1 receptor progressively increased their ethanol intake when subjected to repeated stress; this effect seemed to persist throughout their life (Sillaber et al.
It is clear from this study that CRF1 remains a difficult drug target in the drive to improve current therapies for depression," said Kevin Gorman, president and chief executive officer of Neurocrine Biosciences.
The action of CRF is mediated through G-protein--coupled CRF1 receptors in the pituitary and through CRF1 and CRF2 receptors in brain areas such as the extended amygdala (Dautzenberg and Hauger 2002).
systemically) produced similar effects, suggesting that withdrawal-related anxiety is mediated by CRF1 receptors (Breese et al.
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF 1 receptor antagonist antalarmin and by CRF1 receptor knockout.
Gene-environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1.
Moreover, levels of CRF1 receptors in dependent animals are increased following alcohol withdrawal, and CRF1 antagonists have been shown to reduce alcohol self-administration (for a review, see Heilig and Koob 2007).
Pipeline candidates fall under major therapeutic classes such as Serotonin receptor targets, Guanylate cyclase type C receptor agonist, NK receptor targets, CRF1 receptor agonist.
single nucleotide polymorphisms [SNPs]) in the gene encoding CRF1 were associated with alcohol consumption and a lifetime prevalence of drunkenness in two independent samples (Treutlein et al.