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He also notes that the data suggest that a high sensitivity assay can detect the presence of AMI earlier than with a conventional cTnI assay, and it may also identify more subjects at risk for future adverse events.
This evolution was accelerated once the US Food and Drug Administration approved the use of cardiac troponin T and cTnI during the mid-1990s.
More information on the high sensitivity Acute Care cTnI is available at www.
Whereas our previous work with a sensitive assay for cTnI showed an apparent threshold of risk at the 99th percentile decision limit (21), this work with a high-sensitivity assay further revealed a probable graded pattern of risk below the 99th percentile.
In the multi-center clinical and in-house laboratory studies, the investigational i-STAT System cTnI test whole blood results were compared to plasma results from the Dade Behring Stratus CS(R) instrument.
The ACPP now in use at our hospital uses medical history, ECG, and biomarkers CK-MB, total CK, myoglobin, and cTnI to rule ACS in or out in a 9-hour algorithm.
During the study, commercial QC materials and the same patient pool material were also measured with both the cTnI and hs-cTnI assays on 3 different platforms.
With the addition of cTnI, the capabilities of the i-STAT System are expanded to immunoassays, a major addition to the electrolyte, blood gas, chemistry, coagulation and hematology capabilities already available on the i-STAT System.
3] Nonstandard abbreviations: CK, creatine kinase; TIMI, Thrombolysis in Myocardial Infarction; cTnT, Roche cardiac troponin T; hs-cTnI, high-sensitivity cTnI.
2] presented a study dedicated to evaluating the epitope specificity of auto-antibodies to cTnI (cTnAAbs).
The cTnI 99th percentiles were calculated for the total cohort and prespecified subgroups: men and women, and individuals with and without prevalent CVD.