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CYP2B |
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1988) hypothesized that cetaceans do not possess a group of cytochrome P450 enzymes (known as CYP2B isoenzymes) responsible for the oxidation and activation of halogenated aromatic hydrocarbons, suggesting that these species accumulate some of the toxic PCB congeners and are therefore more susceptible to their long-term effects (Boon et al. Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats. The three structure-activity groups of PCBs were, for group 1, potentially estrogenic and weak phenobarbital inducers (PCB congeners 44, 49, 52, 101, 187, 174, 177, and 157/201); group 2, potentially antiestrogenic and dioxin-like PCBs (PCB congeners 95/66, 74, 77/110, 105/141, 118, 156, 167, 128, 138, and 170); and group 3, phenobarbital and CYP1A and CYP2B inducers (PCB congeners 99, 153, 180, 196/203, and 183). |
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