| Acronym | Definition |
|---|
| CPU | Central Processing Unit (part of a computer system) |
| CPU | Computer Power User (magazine) |
| CPU | Central Policy Unit |
| CPU | Critical Patch Update (Oracle) |
| CPU | Cost Per Unit |
| CPU | Computer Processing Unit |
| CPU | Central Philippine University |
| CPU | Communist Party of Ukraine |
| CPU | Call Pick Up (PABX phone systems) |
| CPU | Commonwealth Press Union (UK) |
| CPU | Contract Postal Unit (US Post Office station) |
| CPU | Crime Prevention Unit |
| CPU | Columbia Pacific University |
| CPU | Customer Pick-Up (shipping/transportation method) |
| CPU | Computer Processor Unit |
| CPU | California Pacific University |
| CPU | California Polytechnic University (aka Cal Poly) |
| CPU | Corporate Procurement Unit |
| CPU | Cash Pick Up |
| CPU | Chest-Pain Observation Unit |
| CPU | Chemical Protective Undergarments |
| CPU | Communications Processor Unit |
| CPU | Contribution Per Unit |
| CPU | Condensate Polishing Unit (water treatment) |
| CPU | Community for Pittsburgh Ultimate |
| CPU | Caption Projection Unit |
| CPU | Certified Postal Unit |
| CPU | Competition Promotion Unit |
| CPU | Clinical Pharmacokinetic Unit |
| CPU | Collective Protection Unit |
| CPU | Chemical Protection Unit |
| CPU | Contrôle de Production en Usine (French: Factory Production Control) |
| CPU | Conférence des Présidents d'Université (French: Conference of University Presidents) |
| CPU | Carnet de Prélèvement Universel (French: Universal Book Collection) |
| CPU | Comprehensive Plan Update (various locations) |