| Acronym | Definition |
|---|
| CFR | Code of Federal Regulations |
| CFR | Cost and Freight (shipping) |
| CFR | Council on Foreign Relations |
| CFR | Case Fatality Rate |
| CFR | Center for Research (various locations) |
| CFR | Campaign Finance Reform |
| CFR | Coronary Flow Reserve |
| CFR | Compagnie Financière Richemont (French finance company) |
| CFR | Carbon Fiber Reinforced |
| CFR | Certified First Responder |
| CFR | Community First Responder |
| CFR | Crest Factor Reduction (algorithm) |
| CFR | Caile Ferate Romane (Romanian Railways) |
| CFR | Confédération Française des Retraités (French: French Confederation of Pensioners) |
| CFR | Crash Fire and Rescue (USMC) |
| CFR | Center for Family Resources |
| CFR | Configuration Register |
| CFR | Channel Frequency Response (communication technology) |
| CFR | Cooperative Fuel Research |
| CFR | Call for Release (FAA) |
| CFR | Constant Failure Rate |
| CFR | Confirmation to Receive |
| CFR | Carbon Film Resistor |
| CFR | Central Forest Reserve |
| CFR | Custom Flat Ride (Atari) |
| CFR | Chicken Fried Rice |
| CFR | Community and Family Resources |
| CFR | Consolidated Fiscal Report |
| CFR | Centre de Formation Régional (French: Regional Training Center; various locations) |
| CFR | Center for Feminist Research (various locations) |
| CFR | Caen, France - Carpiquet (Airport Code) |
| CFR | Commissioning from the Ranks (Canadian military) |
| CFR | Claims Fluctuation Reserve (insurance industry) |
| CFR | Comprehensive Facility Review |
| CFR | Catastrophic Failure Rate |
| CFR | Commercial Fast Reactor |
| CFR | Critical Functional Response |
| CFR | Cumulative Failure Rate |
| CFR | Collège Français de Reus (French: French College of Reus; Reus, Spain) |
| CFR | Contact Flight Rules |
| CFR | Carton Flow Rack (material handling) |
| CFR | Condensate Filter Demineralizer |
| CFR | Franciscan Friars of the Renewal, Fr. Groeschel (religious order) |
| CFR | Centre Fédéral de Ressources (French: Federal Resource Center) |
| CFR | Contractor Flight Release |
| CFR | Contractor Funds Report |
| CFR | Customer Field Representative |
| CFR | Course Frequency Receiver |
| CFR | Carry Forward Form |
| CFR | Coldwater Fishery Resource |
| CFR | Case Form Report |
| CFR | Commission Foncière Rurale (French) |
| CFR | Cartridge Fuse Rating |
| CFR | Computer Facial Recognition |
| CFR | Cylinder Firing Rate |
| CFR | Customer Failure Report |
| CFR | Chemical Functional Review |
| CFR | Can't Find the Road (undefined radio program format) |
| CFR | Conception Fabrication Robotique (French: Manufacturing Robotics Design; Canada) |
| CFR | Cumulative Financial Requirements |
| CFR | Control Filter Rate |
| CFR | Conceptual Feasibility Report |
| CFR | Category for Renaming (Wikimedia Foundation) |
| CFR | Commander Federal Republic |
| CFR | Cleaning Force Ratio |
| CFR | Coordinating Fuel and Equipment Research Committee (Coordinating Research Council, Inc.) |
| CFR | Corporate Family Rating (investment) |
| CFR | Corporate Finance Research |
| CFR | Corporate & Foundation Relations (various schools) |
| CFR | Center for Resolution (various locations) |