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DA is converted to DOPAC intraneuronally after re-uptake, whereas extraneuronal DA is converted to HVA by the enzymes catechol-O-methyltransferase and monoamine oxidase. This genetic alteration reduces the production of the enzyme catechol-O-methyltransferase, or COMT, which helps terminate the action of the neurotransmitters dopamine and norepinephrine, reports a research team headed by psychiatric geneticist Maria Karayiorgou of Rockefeller University in New York. Correlation of erythrocyte catechol-O-methyltransferase activity between siblings. |
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