16) Recent work in our laboratory has shown that in a transgenic PKD2 rat model, the mutant PC-2 (PKD2 [1-703]) induces proliferation in primary tubular epithelial cells in a STAT1/p21 independent fashion and is accompanied by alteration in expression of the cyclin dependent kinase inhibitor p57 and the Cdk2
In order to progress through S-phase, CDK2
and CDK1 need to be assembled with cyclin A and cyclin B.
In general, when the INK group functions in the genetic pathway containing cyclin D-CDK4/6-pRb and E2F, the Cip/Kip group can inhibit CDK2
kinase and CDK4/6 (9), (10).
The labelling index of skp2 in endometrial carcinoma was significantly correlated with that of p27, Ki-67, cdk2
, cyclin A, cyclin D1, cyclin E, p53 and PTEN.
More necently, erythrosin B (dose range: 25-100 [micro]g/mL) has been shown to stimulate proliferation in estrogen receptor (ER) positive HTB 133 cells and to increase Cdk2
activity (dose range: 3-10 [micro]g/mL) in MCF7 cells (Dees et al.
Morgan and Sung-Hou Kim of the University of California at Berkeley had previously determined the structure of CDK2
69 MWold Change CDK1 CDK2
SRGAP3 GTSE1 ITPR1 Res Gene 3.
is activated by cyclin A subunits, and cyclin A is critical for cell cycle control, primarily in the Gl and S phases (Furuno et al.
3] induces p27, inhibiting CDK2
activity, phosphorylation of retinoblastoma protein, and inhibition of DNA synthesis.
These data (Abstract #4972) were presented during a minisymposium on Novel Genomic Approaches, Drugs, Targets, and Strategies in a talk titled "SNS-032, a potent and selective CDK2
, 7 and 9 inhibitor, demonstrates preclinical activity in human multiple myeloma.
P21 inhibits kinase activity and blocks progression through G1 IS by association with CDK2
complexes (Lo et al.
SNS-032 Oral Presentation Tuesday, April 15, 2008 -- SNS-032, a potent and selective CDK2
, 7 and 9 inhibitor, demonstrates preclinical activity in human multiple myeloma Minisymposium: Novel Genomic Approaches, Drugs, Targets, and Strategies Abstract #4972 4:55 p.