MKP1, ERK1, CDK2
and CDK5, CDC25, and MMP9 appear as appealing candidate (Table 1).
The probe-based assays targeting CDK2
and RBL1 recorded similar patterns, with the Cqs recorded for both targets lower in C71A (see online Supplemental Tab 13).
Differential effects of cdk2
and cdk3 on the control of pRb and E2F function during G1 exit.
In this study, the absence of hyperplasia was associated with an alteration in cell cycle progression due to decreased Cdk2
levels and increased p16 and p27 inhibitors.
Inactivation of pRb facilitates expression of E-type cyclins that bind and activate CDK2
during the late G1 and early S phases.
The Cyclin-dependent kinase (CDK), including CDK1, CDK2
, CDK4 and CDK6, is very important to activate cell cycle (Andrew at al.
1991) A new human p34 protein kinase, CDK2
, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
El gen cdc25A codifica para una proteina fosfatasa que a su vez activa a CDK2
RAD51L1 phosphorylates a number of proteins, including TP53, cyclin E, and CDK2
, suggesting that RAD51L1 affects cell cycle progression (6).
We have previously shown that TCDD treatment suppresses CDK2
activity and decreases formation of CDK2
/cyclin E complexes.
Mammary tumors initiated by constitutive Cdk2
activation contain an invasive basal-like component.
A particularly interesting finding was that a recurrent chimeric transcript was found involving the CDK2
gene, known to be required for melanoma cell proliferation.