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3 million) to a multi-national effort to develop laser-based technologies and tools for use in genome-wide chromatin immunoprecipitation analyses, which are used to understand regulatory circuits that control development. This edition contains several new chapters on chromatin immunoprecipitation and other in vivo technologies, and new chapters on topological studies, photo crosslinking, FRET, and imaging techniques. One of these new powerful techniques is called chromatin immunoprecipitation on chip (ChIP on chip), a method that was designed initially to identify binding sites of transcription factors in yeast5 and cultured human cells. |
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