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Neuroendocrine markers, such as chromogranin A, neuron-specific enolase (NSE), synaptophysin, and insulin growth factor II (IGF II) are specific to pheochromocytomas and paragangliomas, and are not present in hepatocellular tumors. Further immunohistochemical analysis with neuroendocrine markers stained strongly positive for chromogranin A and neuron-specific enolase, and the lesion was designated as an atypical carcinoid tumor (figure 1, B). Immunohistochemical staining for $100 was performed to characterize malignant schwannoma, whereas chromogranin A staining was used to characterize olfactory neuroblastomas. |
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