| Acronym | Definition |
|---|
| COM | Commercial (Internet top level domain) |
| COM | Common |
| COM | Communications |
| COM | Command (File Name Extension) |
| COM | Component Object Model (Microsoft) |
| COM | Component Oriented Middleware |
| COM | Complete (railroads) |
| COM | Community |
| COM | Cost of Money (finance) |
| COM | Customer's Own Material |
| COM | Commercial |
| COM | Change of Mission |
| COM | College of Communication (Boston University) |
| COM | College of Medicine |
| COM | Center Of Mass |
| COM | Customer Operations Manager |
| COM | Committee of Management |
| COM | Committee |
| COM | Common Object Model |
| COM | Chief of Mission |
| COM | Chief Of Maintenance |
| COM | Comedy Central (cable network) |
| COM | Comedy |
| COM | Comoros (ISO Country code) |
| COM | Chain of Memories (Kingdom Hearts video game) |
| COM | Commission On Ministry |
| COM | commander (US DoD) |
| COM | Clinical Operations Manager |
| COM | Communicate |
| COM | Cost Of Manufacture |
| COM | Council on Ministries |
| COM | Center for Optics Manufacturing |
| COM | Consequence Management |
| COM | College of Marin |
| COM | Cabinet of Ministers |
| COM | Commodore |
| COM | College of the Mainland (Texas City, Texas) |
| COM | Captain of Marines |
| COM | Contamination Monitor |
| COM | Comma |
| COM | Creepy Old Man |
| COM | Colloidal Organic Matter |
| COM | College of Osteopathic Medicine |
| COM | Computer Output Microfiche |
| COM | Continuous Opacity Monitor (environment) |
| COM | Chronic Otitis Media |
| COM | Count on Me |
| COM | Commutator (part of an electric motor) |
| COM | Comite Olimpico Mexicano (Mexican olympic participation agency) |
| COM | Campers on Mission |
| COM | Company Operations Manual |
| COM | Council of Mages (game) |
| COM | Continuation Of Message (ATMF) |
| COM | Component Object Module |
| COM | Crown of Might (game) |
| COM | Corporal of Marines |
| COM | Colonel of Marines |
| COM | Círculo de Oficiales de Mar (Argentina) |
| COM | Council On Ministry (United Methodist Church) |
| COM | Commissioned Officers Mess |
| COM | Coal-Oil Mixture |
| COM | Commodity Options Market |
| COM | Collection Operations Management |
| COM | Computer Operations Manual |
| COM | Central Office Module |
| COM | Coupling-Of-Mode |
| COM | Commission on Overseas Mission |
| COM | Cockpit Operating Manual |
| COM | Conventiei Organizatiilor de Media (Romanian) |
| COM | Character-Oriented Message |
| COM | Cowl of Mortality (gaming) |
| COM | Change Order Master |
| COM | Commissary Operating Manual |
| COM | Country of Origin Minimum Check (city/airport code) |
| CoM | Church of Miho (Megatokyo religion) |
| COM | Customer's Own Merchandise |
| COM | Crystallographic Orientation Matrix |
| COM | Client-Owned Material |
| COM | Computer-Output Microfilm/Microform |
| COM | Calcium Oxalate Monohydrate |
| COM | Council of Management (UK) |
| COM | Centre d'Océanologie de Marseille (French: Oceanology Center of Marseilles; Marseilles, France) |
| COM | Culture, Organization and Management |
| COM | Contrat d'Objectifs et de Moyens (French: Contract Objectives and Means) |
| COM | Collectivité d'Outre-Mer (French: Overseas Communities) |