| Acronym | Definition |
|---|
| CFR | Code of Federal Regulations |
| CFR | Cost and Freight (shipping) |
| CFR | Council on Foreign Relations |
| CFR | Campaign Finance Reform |
| CFR | Case Fatality Rate |
| CFR | Coronary Flow Reserve |
| CFR | Certified First Responder |
| CFR | Crest Factor Reduction (algorithm) |
| CFR | Carbon Fiber Reinforced |
| CFR | Caile Ferate Romane (Romanian Railways) |
| CFR | Center for Family Resources |
| CFR | Community First Responder |
| CFR | Channel Frequency Response (communication technology) |
| CFR | Crash Fire and Rescue (USMC) |
| CFR | Cooperative Fuel Research |
| CFR | Call for Release (FAA) |
| CFR | Confirmation to Receive |
| CFR | Configuration Register |
| CFR | Central Forest Reserve |
| CFR | Constant Failure Rate |
| CFR | Carbon Film Resistor |
| CFR | Consolidated Fiscal Report |
| CFR | Community and Family Resources |
| CFR | Center for Feminist Research (various locations) |
| CFR | Caen, France - Carpiquet (Airport Code) |
| CFR | Commissioning from the Ranks (Canadian military) |
| CFR | Claims Fluctuation Reserve (insurance industry) |
| CFR | Comprehensive Facility Review |
| CFR | Catastrophic Failure Rate |
| CFR | Commercial Fast Reactor |
| CFR | Critical Functional Response |
| CFR | Cumulative Failure Rate |
| CFR | Contact Flight Rules |
| CFR | Carton Flow Rack (material handling) |
| CFR | Coldwater Fishery Resource |
| CFR | Condensate Filter Demineralizer |
| CFR | Franciscan Friars of the Renewal, Fr. Groeschel (religious order) |
| CFR | Contractor Funds Report |
| CFR | Contractor Flight Release |
| CFR | Customer Field Representative |
| CFR | Course Frequency Receiver |
| CFR | Carry Forward Form |
| CFR | Can't Find the Road (undefined radio program format) |
| CFR | Commission Foncière Rurale (French) |
| CFR | Case Form Report |
| CFR | Cartridge Fuse Rating |
| CFR | Computer Facial Recognition |
| CFR | Cylinder Firing Rate |
| CFR | Customer Failure Report |
| CFR | Chemical Functional Review |
| CFR | Cumulative Financial Requirements |
| CFR | Control Filter Rate |
| CFR | Conceptual Feasibility Report |
| CFR | Commander Federal Republic |
| CFR | Cleaning Force Ratio |