| Acronym | Definition |
|---|
| CLE | Continuing Legal Education |
| CLE | Community Legal Education |
| CLE | Clear Lens Extraction (ophthalmic surgery) |
| CLE | Customer Located Equipment |
| CLE | Council for Leather Exports (India) |
| CLE | Certified Lactation Educator |
| CLE | Congenital Lobar Emphysema |
| CLE | Chinese Linux Extension |
| CLE | Centre for Logic, Epistemology and the History of Science (São Paulo, Brazil) |
| CLE | Centre Linguistique pour Etrangers |
| CLE | Cray Linux Environment (software) |
| CLE | Core Language Engine (SRI Cambridge Computer Science Research Centre) |
| CLE | columnar-lined esophagus |
| CLE | Centre de Loisirs Éducatifs (French: Educational Entertainment Center) |
| CLE | Coopération Linguistique et Éducative (French: Linguistic and Educational Cooperation) |
| CLE | Construction Licensing Executive |
| CLE | Crystal Lake Elementary (Florida) |
| CLE | Cleveland, OH, USA - Hopkins International Airport (Airport Code) |
| CLE | Continuing Learning Experience |
| CLE | Christian Life Education (Philippines) |
| CLE | Complete Local Excision |
| CLE | Command Launch Equipment |
| CLE | Cree Leukoencephalopathy |
| CLE | Continuous Lumbar Epidural |
| CLE | Career Limiting Event |
| CLE | California Law Examination |
| CLE | Cottage Lane Elementary (Blauvelt, NY) |
| CLE | Commission Locale d'Environnement (French: Local Environment Committee) |
| CLE | Classical Literacy Exam |
| CLE | Common Learning Experience |
| CLE | Control Law Electronics (aerospace engineering) |
| CLE | Customer Liaison Engineer |
| CLE | Centro Logistico Europeo |
| CLE | Centre for Legal Education (various locations) |
| CLE | Command Line Editor (computing) |
| CLE | Criminal Law Enforcement (various locations) |
| CLE | Current Limiting, E-Rated (electrical engineering) |
| CLE | Commercial Landscape Estimator |
| CLE | Collège Lycée Expérimental (French experimental school) |
| CLE | Center for Leadership Education (various organizations) |
| CLE | Cap Lillois pour Entreprendre (French employment initiative) |
| CLE | Centre Locaux d'Emploi (French: Local Job Center; Canada) |
| CLE | Chinese Language Education |