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CYP1A |
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Oxidative inactivation of cytochrome P450 1A stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Cytochrome P450 1A (CYP1A) induction is elicited by PAHs and PHAHs via binding to the aryl hydrocarbon receptor (AHR) (Whitlock 1999). Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops). |
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