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Related to DDIT3: HSPA5
DDIT3DNA-Damage-Inducible Transcript 3
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Supporting this hypothesis, tumor samples excised from the treated animals exhibited higher expression of DDIT3 and lower levels of ALDH1A3, an isoform of aldehyde dehydrogenase found to be over expressed in pemetrexed + cisplatin resistant MPM cells, which augments the chemosensitizing effect of butein (Canino et al.
1) Five split-apart probe sets are used at our institution to evaluate most translocations including probes to the EWSR1, FUS, DDIT3, SYT, and FOXO1A genes (Abbott Molecular/Vysis, Des Plaines, Illinois).