DETAPACDiethylenetriaminepentaacetic Acid
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After the total incubation period (24 days), the fluorescence of corneal collagen had increased only slightly in the presence of aspirin, aminoguanidine and DETAPAC but somewhat more when paracetamol, ibuprofen or vitamin E were used and to an even greater extent with vitamin C.
DETAPAC and AG inhibit the conversion of the Amadori product to an AGE.
With the exception of DETAPAC and aminoguanidine, which are relatively toxic, we have shown that the other inhibitors, aspirin, paracetamol, iboprofen, vitamin C and vitamin E, are suitable for preventing the structural effects of glycation on collagen in vitro and also, probably, in vivo.