In this current study, the results from five clinical trials were integrated into a database to examine the safety and efficacy of the DETP by injury location.
Fisher's exact test was used to compare the frequencies of AEs between the DETP and placebo treatments.
Concentrations were summed to obtain overall concentrations of diethylphosphate metabolites (DE; sum of DEP, DETP, and DEDTP), dimethylphosphate metabolites (DM; sum of DMP, DMTP, and DMDTP), and all six nonspecific dialkylphosphate metabolites.
45 [micro]g/L for DEP, DETP, DEDTP, DMP, DMTP, and DMDTP, respectively; LOD were 0.
It is also worth noting that studies on PON1 have focused on pesticides such as chlorpyrifos, diazinon, and parathion, which metabolize into DEP and DETP
, whereas other OPs such as malathion, azinphos methyl, and dimethoate metabolize into DMP and DMTP (Maroni et al.
Volume-based median concentrations of DEP and DETP
were converted to molar concentrations and summed to examine trends in the cumulative concentration of these metabolites.
Thus, if DEP and DETP
are detected in the urine sample, one could conclude only that exposure to an O,O-diethyl-substituted pesticide or its environmental degradate has occurred.
We cannot readily explain the apparent increase in OP metabolite levels and the upward shift in the ratio of DEP to DETP
+ DEDTP in the postpartum period.
The infrequent detection of DEP and DETP
in our survey is consistent with the experience of researchers at the University of Washington (Curl et al.
The 95th percentiles for each metabolite were DMP, 13 [micro]g/L; DMTP, 46 [micro]g/L; DMDTP, 19 [micro]g/L; DEP, 13 [micro]g/L; DETP
In a study of farmworkers and their children in California, Mills and Zahm (2001) found DMP, DMTP, and DETP
more often in the urine of children than in that of their farmworker parents.
The metabolites include dimethyl phosphate, DMTP, dimethydithiophosphate, diethyphosphate, DETP
, and diethyldithiophosphate.