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DFCI

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DFCIDana-Farber Cancer Institute


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2) The DFCI protocols involve a month-long period of intensive multiagent chemotherapy to induce remission, after which the children receive a 2-year course of systemic multiagent chemotherapy and prophylaxis to reduce the risk that leukemic cells would continue to proliferate in the CNS.
Preclinical studies performed by the DFCI and the National Cancer Institute suggest that Talotrexin, as compared to methotrexate, the most widely used antifolate, enters into cells up to 10 times more efficiently and demonstrates 10- to 100-fold more potency in overcoming polyglutamation, a well-established mechanism of antifolate resistance.
E[acute accent]As a result of the FTP-based batch integration, DFCI is able to export online and offline donor transactions and related data from the Kintera Sphere database into PledgeMaker on a daily basis, saving the organization time and resources.
 
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