Palfreyman and Schechter were also key players on the DFMO
team 30 years ago, and Dr.
The second goal is to follow upfront chemotherapy with maintenance therapy using DFMO
to prevent relapse in patients with newly diagnosed high-risk neuroblastoma.
So we believe the DFMO
trial, which has been hugely successful on other children, represents Lily-Mae's best hope.
2] Nonstandard abbreviations: HPV, human papillomavirus; FAP, familial adenomatous polyposis; AK, actinic keratosis; PCPT, Prostate Cancer Prevention Trial; SELECT, Selenium and Vitamin E Cancer Prevention Trial; BCPT, Breast Cancer Prevention Trial; CARET, Beta-Carotene and Retinol Efficacy Trial; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention (trial); NSAID, nonsteroidal anti-inflammatory drug; FDA, US Food and Drug Administration; STAR, Study of Tamoxifen against Raloxifene; SERM, selective estrogen receptor-modulating agent; BCG, bacille Calmette-Guerin; DFMO
, [alpha]-difluoromethylornithine (eflornithine).
is a cost effective alternative to melarsoprol for the treatment of second stage human West-African trypanosomiasis in Caxito, Angola.
Specifically, an adenoma was found in 42 of 97 patients who received placebo and completed the trial (43%), compared with 12 of 107 on the DFMO
/sulindac combination (11%).
of the University of California, Irvine and his colleagues have completed nearly two decades of testing very low doses of DFMO
in people who are at high risk for colorectal cancer.
Sadly though, DFMO
is expensive and production ceased in 1999.
John said: "It's a trial that is testing a drug called DFMO
which they hope will prevent a relapse.
Genzyme acquired certain rights to eflornithine, also known as DFMO
, through its purchase of Ilex Oncology Inc.
Migration of RPE cells treated with DFMO
was reduced to [sim]40% of control levels, and the results were reversed to [sim]96% with spermine addition.
is orally available, it has potential to fulfill this currently unmet therapeutic need.