The mechanism of benefit of DGLA
is not fully understood as yet.
GLA's systemic influence lies in the conversion of its intermediate DGLA into anti-inflammatory, signalling molecules called eicosanoids.
This disease has a foundation in fatty acid abnormalities, with particularly low DGLA and high ARA levels in nerve membranes and red blood cell membranes.
Moreover, GLA, DGLA, DPA6, and EPA concentrations in plasma as well as DGLA, DPA6, and EPA concentrations in erythrocyte membranes were increased in pancreatic insufficient patients.
We observed no significant influence of sex on the AA/ DGLA ratio.
Therefore, direct dietary supplementation of GLA is often required to ensure that adequate levels of PGE1 and 15-OH DGLA are synthesized by the body.
GLA supplementation is used for the production of PGE1 and 15-OH DGLA and to normalize the production of AA derived eicosanoids and, thus, control or cure several disease states.
Groupement EGE (mandataire) DGLA
Sud / Allie~Air / ab Ingenierie / Quassi 140 quai Flora Tristan - 34070 Montpellier.
Increased dietarv intakes of GLA or DGLA
have been shown to increase prostaglandin E-l (PGE-1) which suppresses PGE-2 production.
0 g/d also resulted in an enrichment of DGLA
in neutrophil phospholipids but no change in GLA or AA levels.