Compounds with the highest a priori likelihood in favor of an effect were, on the basis of animal studies, DEHP, bisphenol A, and, to a lesser extent, DINP
In the earlier study, published in May in the Journal of Clinical Endocrinology and Metabolism, the same NYU investigators found an association between DINP
and DIDP concentrations and increased insulin resistance, a precursor to diabetes.
Why toy is a potential hazard: The plastic portion of the backpack contains 200,000 ppm of the phthalate DEHP and 3,000 ppm DINP
, both of which are banned above 1,000 ppm.
Abbreviations EDCs -endocrine disrupting chemicals DEHP -di (2-ethylhexyl) phthalates MEHP -mono(ethyl-hexyl) phthalate BBzP -butyl benzyl phthalate DBP -di-n-butyl phthalate DINP
-di-isononyl phthalate DIDP -di-isodecyl phthalate DMP -di-methyl phthalate DnOP -di-n-octyl phthalate MEP -mono-ethyl phthalate MBP -mono-butyl phthalate MMP -mono-methyl phthalate
Later, in response to a petition by environmental groups to ban PVC in children's products, a CHAP Report (June 2001) concluded that DINP
in toys, teethers, and rattles was not hazardous to children, and CPSC denied the petition in 2003.
The phthalate diffusion values in the saliva for DEHP and DINP
The 2005 study had found that anywhere from 10 percent to 54 percent of the total content of tested toys consisted of DEHP or DINP
Other studies have linked phthalates like DINP
to rodent cancers and genital abnormalities, especially in males.
Three other variants, DINP
, DIDP and DNOP, will be banned in toys and other child care items that can be placed in the mouth.
The three other phthalates - DINP
, DIDP and DNOP - are banned, for the same concentrations, in toys and childcare articles which children could put in their mouths, whether or not they are intended for this use.
Perinatal exposure to the phthalates DEHP, BBP, and DINP
, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.
Phthalates, such as DEHP and DINP
, are plasticizers that make hard plastics flexible: they have been used in various products including vinyl, medical equipment, and some baby toys.