The above combined with the favorable effect of the discontinuation of treatment with fenofibrate is highly suggestive that the patient's of DITP was caused by this agent.
The estimated annual incidence of DITP is about 10 cases per million persons per year (4).
Immune-mediated DITP caused by peripheral platelet destruction is our case.
Immune-mediated DITP is an idiosyncratic reaction which an unusual class of drug-dependent antibodies binds firmly to specific epitopes on platelet surface glycoproteins.
In general, the pathogenesis of immune-mediated DITP is quite complex, and at least 6 different specific mechanisms have been proposed (11).
The diagnosis of DITP requires that an antibody that reacts with normal platelets in the presence of the responsible drug, which drug the patient has received, be detected.
As for the treatment of DITP, as most drugs are cleared within a few days, PLT levels often start to increase within a day or 2 of hospital admission, so drug discontinuation usually results in a recovery from thrombocytopenia.
to end users, including power equipment designed by the EDA / DITP
(Escalators, elevators PMR, shutters, pumping stations, advertising valves, etc .