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DNMT |
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Specific forms of DNMT include DNMT1, which is considered important for maintenance and is constitutively expressed in adult cells, and DNMT3a and 3b, which have strong de novo activity (Das and Singal 2004) and are highly expressed in embryonic cells (Okano et al. Estrogen receptor genes are found to be silenced, or turned off, in human breast cancer cells and thus the reactivation of these genes using HDAC and DNMT inhibitors may provide insight in developing drug targets to treat breast cancer. In a separate program, the Company has identified isoform-selective small molecule inhibitors of the DNMT enzymes. |
DNMT |
DNLE DNLEU DNLG DNLL DNLP DNLR DNLS Dnm Dnm1p/Vps1p-Like Protein DNMC DNMEP DNMES DNMF DNMG DNMI DNML DNMM DNMP DNMR DNMRT DNMS DNMSL DNMSP DNMSS-G/NEC DNMT DNMTPDNMTS DNMU DNMV DNMW DNN Dnna DNNF DNNIC DNNY DNNYC Dno Dno Dno, Russia DNOA DNOC DNOC DNOCA DNOI DNOJ DNOP DNOS DNOS DNOSP DNOTC DNOV DNP DNP | |||||
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