DNMT


Also found in: Medical.
AcronymDefinition
DNMTDNA Methyl Transferase
DNMTdo not move this
DNMTDefinitely Not My Type
References in periodicals archive ?
Interestingly, a previous animal study found that the effects of lead exposure on DNMTs and DNA-binding proteins in the hippocampus appear to be different in males and females and are further differentiated by the period of development during which exposure occurs (Schneider et al.
El tratamiento en combinacion de inhibidores de DNMT y HDAC ha mostrado eficacia; por los menos en un ensayo clinico donde se exploro la combinacion de 5-azacitidina con entinostat, un inhibidor de HDAC, para el tratamiento de pacientes con NSCLC refractarios al tratamiento con quimioterapia [46].
Maintenance methylation is simply DNMTs maintaining methylation patterns necessary for normal cellular functioning.
Two categories of chemical compounds containing the DNMT inhibitor enzyme and HDAC under clinical trials and research in recent years are before it.
In addition, transcriptional expression of all three catalytically active DNMTs (1,3a, and 3b) was studied in the GHRKO/BP mouse at 3, 12 and 24 months of age.
sup][20] Through the CXXC binding domain, TET1 prefers to bind hypomethylated, high CpG-dense regions (such as CGIs, gene promoters) to prevent DNMT activity and inhibit DNA methylation.
In vitro [132] and in vivo [133] studies demonstrate that ROS induce general genome hypomethylation and specific DNA promoters hypomethylation, via the DNMT upregulation and the DNMT complexes generation.
Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore.
DNMT1, which also is referred to as the maintenance DNMT, completes the methylation of the par tially methylated (i.
11) El mantenimiento y control de la metilacion en el ADN dependen principalmente de la presencia de las DNMT (DNA-methyltransferases) y de otras metiltransferasas como DNMT 3a y DNMT 3b, que parecen ser mas importantes en la etapa embrionaria (12) y tienen una preferencia regional en las islas CpG ubicadas en la porcion junto al centromero.