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No Association between the Response to Methylphenidate and DRD4 Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder: A Case Control Study.
DRD4 is one of several genes that determines the way dopamine -- a crucial neurotransmitter, or chemical messenger -- is released in the brain.
Association study of DRD4 exon‡V48 bp variable number of tandem repeats polymorphism and tic disorder (in Chinese).
Besides DRD4 and DAT1, Qian  also investigated the 241 A > G polymorphism of DRD2, which showed no significant difference between ADHD cases and controls even after stratification by gender or subtype; she also found no evidence of gene-gene interactions among dopamine candidate genes.
When an additional 386 skiers were questioned she found the same association between the variation of the DRD4 gene and a willingness to take risks on the slopes.
This derivative of a dopamine-receptor gene - called the DRD4 7R allele - appears in significantly higher rates in people more than 90 years old and is linked to lifespan increases in mouse studies.
Certain polymorphisms of the DRD2 and DRD4 genes are involved in the abuse of multiple substances, age of onset in the psycho-stimulants abuse and dependence (4); (c) Dopamine transporter (DAT).
Genetic variables could include serotonergic genes (serotonergic receptors [5HT2a]; serotonin transporter 5HTlPR); endorphinergic genes (mu OPRM1 gene; proenkephalin [PENK, PENK polymorphic 3' UTR dinucleotide (CA) repeats]; GABergic gene (GABRB3), and dopaminergic genes (ANKKI Taq A; DRD2 C957T, DRD4 7R, COMT Val/met substation; MAO-A uVNTR; and SLC6A3 9 or 10R).
One human gene that personality researchers have focused on is called DRD4, which encodes a dopamine receptor and is thought to play a role in exploration and novelty-seeking behavior.
DRD2, DRD3 and DRD4 exert opposite effects and decrease cAMP production through inhibition of adenylyl cyclase activity.
Researchers quizzed 180 young men and women about their attitude towards relationships and tested them for a gene called DRD4, which affects levels of the brain chemical dopamine.
Bunlardan en fazla uzerinde durulan ve olumlu bulgularin elde edildigi genler DRD4 ve DAT1 genleridir.
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