| Acronym | Definition |
|---|
| DES | Data Encryption Standard (US) |
| DES | Description (File Name Extension) |
| DES | Destination |
| DES | Designation |
| DES | Descent |
| DES | Destroyer (short form) |
| DES | Diethylstilbestrol |
| DES | Diplôme d'Etudes Supérieures (French: Higher Education Diploma) |
| DES | Department of Environmental Services (New Hampshire) |
| DES | Drug Eluting Stent |
| DES | Diplôme d'Études Spécialisées (French: higher education) |
| Des | Designator |
| DES | Department of Economic Security (Arizona) |
| DES | Discrete-Event Simulation |
| DES | Department of Education and Science |
| DES | Digital Elevation Model |
| DES | Department of Emergency Services (Australia) |
| DES | Delivered Ex Ship (shipping) |
| DES | Desmin |
| DES | Discrete Event System |
| DES | Detached-Eddy Simulation |
| DES | Disability Evaluation System (US military) |
| DES | Disaster and Emergency Services |
| DES | Directorate of Emergency Services |
| DES | Department of Employment Services |
| DES | Director of Emergency Services |
| DES | Division of Engineering Services (Indian Health Service; US DHHS) |
| DES | Division of Earth Sciences |
| DES | Division of Emergency Services (FEMA) |
| DES | Disaster Emergency Services (FEMA) |
| DES | Dissociative Experience Scale (human psychology) |
| DES | Draft European Standard |
| DES | Dietary Energy Supply (Refers to number of calories consumed daily per person) |
| DES | Division of Environmental Services |
| DES | Data Entry Sheet |
| DES | Draft Environmental Statement |
| DES | Destination End System |
| DES | Division of Environmental Sciences |
| DES | Direction des établissements de Santé (French; Senegal) |
| DES | Digital Encryption System(s) |
| DES | Data Element Standardization |
| DES | Division of Economic Support (Wisconsin) |
| DES | Dysequilibrium Syndrome |
| DES | Delaware Engineering Society |
| DES | Departamento de Economia da Saúde (Portugese, Brazil) |
| DES | Diabetes Education Society |
| DES | Diploma in English Studies |
| DES | Directorate of Evaluation and Standardization |
| DES | Doppler Echocardiography Study |
| DES | Drilling Equipment Set (oil industry) |
| DES | Doctor of Environmental Studies |
| DES | Distributed End System |
| DES | Data Enhancement System (NASA) |
| DES | Digital Electronic Signal |
| DES | Dynamic Environmental Scan |
| DES | Data Extraction Segment |
| DES | Dewar Elementary School (Valdosta, GA) |
| DES | Dental Equipment Set |
| DES | Dismounted Entry Switch |
| DES | Digital Echo Suppressor |
| DES | Data Entry Specification |
| DES | Digital Extend Signal |
| DES | Digital Electronic Switch |
| DES | Debt Elimination Specialists LLC |
| DES | Differential Evolution Strategy |
| DES | Data Erased Systematically |
| DES | Distribution and Execution System (Army) |
| DES | Di-2-Ethylhexel Sebecate |
| DES | Data Editing Subsystem |
| DES | Dealer Evaluation System |
| DES | Digital Electronics Sub-System |
| DES | DOSECC (Drilling, Observation and Sampling of the Earth's Continental Crust) Exploration Services, LLC (Salt Lake City, UT) |