| Acronym | Definition |
|---|
| DOC | Department Of Commerce |
| DOC | Microsoft Word File (file extension) |
| DOC | Document/Documentation (file name extension) |
| DOC | Doctor |
| DOC | Data-Over-Cable |
| DOC | Department Of Corrections |
| DOC | Department Of Conservation (New Zealand) |
| DOC | Duty of Care |
| DOC | Drug of Choice |
| DOC | Director of Communications |
| DOC | Department Of Communications (Canada) |
| DOC | Documentation of Compliance |
| DOC | Diesel Oxidation Catalyst |
| DOC | Deck of Cards |
| DOC | Document/Documentation |
| DOC | Depth of Cut (machine tooling) |
| DOC | Defamation of Character |
| DOC | Dominion of Canada |
| DOC | Daughters of the Confederacy |
| DOC | Deoxycorticosterone |
| DOC | Directorate Of Contracting |
| DOC | Dartmouth Outing Club |
| DOC | Doctors Opposing Circumcision |
| DOC | Dimensions of Culture |
| DOC | Doctors on Call (Caribbean surgical outreach organization) |
| DOC | Department Operations Center |
| DOC | Doctors Ought to Care |
| DOC | Debugging Optimized Code |
| DOC | Director of Catering |
| DOC | Day of Contempt (band) |
| DOC | Director On Call |
| DOC | Dynamic Overload Control |
| DOC | Digital Oscillator Chip (Ensoniq 5503 DOC) |
| DOC | Designated Operational Coverage (navigation aids) |
| DOC | 2,5-Dimethoxy-4-Chloroamphetamine |
| DOC | Daily on Call |
| DOC | Decommissioning Operations Contractor |
| DOC | Desired Operational Capability |
| DOC | Dead on Contact |
| DOC | Data Operations Control |
| DOC | Disciples of Christ |
| DOC | Development Operations Corporation (Fort Meyers, FL) |
| DOC | Denominazione di Origine Controllata (Italian: Checked Origin Name) |
| DOC | Declaration of Conformity |
| DOC | Discipline Operations Center |
| DOC | Data Optimizing Computer |
| DOC | Dissolved Organic Carbon |
| DOC | Distributed Operational Control |
| DOC | Design and Order Confirmation |
| DOC | Descend on Course |
| DOC | Digital Office Committee |
| DOC | Data Operations Controller |
| DOC | Ding'Opel Club (French car club) |
| DOC | Daily Operations Coordinator |
| DOC | Defenders of Camelot (gaming guild) |
| DOC | Date of Conception |
| DOC | Designed Operational Code |
| DOC | Dominação de Origem Controlada (Portugal) |
| DOC | Due Out Cancellation |
| DOC | Degree Of Cooperation |
| DOC | Double-O Club (James Bond fan club; Denmark) |
| DOC | Disk on Chip |
| DOC | Date Of Change |
| DOC | Day Old Chick |
| DOC | Direct Operating Cost |
| DOC | Distributed Object Computing |
| DOC | Digital Optics Corporation |
| DOC | Deoxycholate |
| DOC | Disaster Operations Center (American Red Cross) |
| DOC | Director of Operational Capability (UK) |
| DOC | Disturbo Ossessivo Compulsivo (Italian: Obsessive Compulsive Disorder) |
| DOC | Défibrillateur Opérationnel Connecté (French: Connected Operational Defibrillator) |
| DOC | Declaration of Conduct (various nations) |
| DOC | Date of Contact |
| DOC | Diabetes Online Community (est. 2005) |
| DOC | Department of Organic Chemistry (various locations) |
| DOC | Department of Cybernetics |
| DOC | Designed Operational Capability (US DoD) |
| DOC | Data Operations Center |
| DOC | DAF (Van Doorne's Automobiel Fabriek) Owners Club (UK) |
| DOC | Dean of the College (various schools) |
| DOC | Digital Opportunity Center (various locations) |
| DOC | Desmo Owners Club (bikes) |
| DOC | Division of Community Corrections (various locations) |
| DOC | Distribution Operation Center |
| DOC | Digital Output Channel |
| DOC | Department Of Corporation (California) |