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Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hyper transfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. The patient received frequent blood transfusions and monthly intravenous deferoxamine for secondary hemochromatosis. Among the recognizable risk factors for the development of RCM are poorly controlled diabetes, hematologic malignancies, acquired immunodeficieney syndrome, severe bums, renal diseases, malnutrition, iatrogenic immunosuppression after organ transplantation, and deferoxamine therapy. |
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