| Acronym | Definition |
|---|
| DDI | Didanosine (aka Videx; antiretroviral drug) |
| DDI | Development Dimensions International, Inc. |
| DDI | Device Driver Interface |
| DDI | Dideoxyinosine |
| DDI | Drug-Drug Interaction |
| DDI | Duke Digital Initiative (Duke University) |
| DDI | Direct Dialing In |
| DDI | Dansk Døve-Idrætsforbund |
| DDI | Don't Do It |
| DDI | Direct Debit Instruction (UK finance & banking term) |
| DDI | Direct Debit Instruction |
| DDI | Discado Directo Internacional (Spanish: international direct dial) |
| DDI | Discagem Direta Internacional (Brazilian Portuguese: direct international dialing) |
| DDI | Deputy Director of Intelligence (US CIA) |
| DDI | Device Dependent Interface |
| DDI | Dairy Development International, LLC |
| DDI | Data Directions Inc. (Virginia) |
| DDI | Design, Develop, and Implement |
| DDI | Digital Display Indicator |
| DDI | Data and Dimensions Interface |
| DDI | Dartmouth Debate Institute |
| DDI | Director of Defense Information |
| DDI | Día de Independencia (Spanish: Independence Day) |
| DDI | Diagnostic Digital Imaging |
| DDI | Direct Deposit Indicator |
| DDI | Digital Data Interpreter |
| DDI | Distilled De-Ionized (water) |
| DDI | Digital Data Indicator |
| DDI | Director Defense Information |
| DDI | Depth Deviation Indicator |
| DDI | Duty Director for Intelligence |
| DDI | Database Data Interchange |
| DDI | Dedicated Display Indicator (NASA) |
| DDI | Discrete Digital Input |
| DDI | Dummy, Drill and Inert (training ammunition) |
| DDI | Discrete Data Input (NASA) |
| DDI | Daini-Denden Planning Company (Japan, now KDDI) |
| DDI | Dynamic Dies, Inc. (est. 1971) |
| DDI | Database Designing Incorporated |
| DDI | Decoy-DECM Integration |
| DDI | Dynamic Data Interchange |
| DDI | Digital Design Initiative |
| DDI | Diamond Design, Inc. |
| DDI | Demand Display Index |
| DDI | Drivers Display Interface |
| DDI | Direct Dial Information |
| DDI | Document Data Index (configuration management) |