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DXODefence Executive Officer (Ministry of Defence; Singapore)
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CYP2D6 activity was assessed by the formation of dextrorphan from the CYP2D6 probe dextromethorphan (Sun et al.
Dextromethorphan DM, dextrorphan DOR, 3-methoxymorphinan 3MM, levallorphan (internal standard, IS) and [beta]-glucoronidase (Type IX-A) were purchased from Sigma Chemical Corp.
6] Nonstandard abbreviations: PM, poor metabolizer; UM, ultrarapid metabolizer; AS-PCR, allele-specific PCR; DXT, dextromethorphan; MR, metabolic ratio; SSPE, sodium chloride-sodium phosphate-EDTA; IM, intermediate metabolizer; EM, efficient metabolizer; and DRP, dextrorphan.
Dextromethorphan, dextrorphan, quinidine, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), D-glucose 6-phosphate, glucose 6-phosphate dehydrogenase, heparin sodium, urethane, and phenacetin were from Sigma Chemical Co.
The dextromethorphan/ dextrorphan ratio was used to classify participants as poor or extensive metabolizers (27).
The incidence of reported adverse events was higher in dosing regimens with higher peak concentrations of dextromethorphan (DM) or its metabolite product dextrorphan (DX).
Metabolism of dextromethorphan to dextrorphan (CYP2D6-mediated) and chlorzoxazone to 6-hydroxychlorzoxazone (CYP2E1-mediated) was only minimally inhibited by PSP, with [IC.
This study evaluated radioligand competitive binding for memantine, amitriptyline, fluoxetine, dextrorphan and dextromethorphan, the therapeutically active ingredient in Zenvia, to determine the binding affinities for each drug to 26 different target receptor binding sites in the brain.
Phenacetin, paracetamol, warfarin, furafylline, testosterone, 613-hydroxytestosterone, ketoconazole, 4-hydroxytolbutamide, tolbutamide, chlorzoxazone, 6-hydroxychlorzoxazone, chlorpropamide, chlorpheniramine, dextromethorphan, dextrorphan, sodium diethyl-dithiocarbamate, glucose 6-phosphate dehydrogenase (G6PDH), D-glucose 6-phosphate (G6P), [beta]-nicotinamicle adenine dinucleotide phosphate (NADP), and Tris-HCI were purchased from Sigma Chemical Co.