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DXODefence Executive Officer (Ministry of Defence; Singapore)
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CYP2D6 activity was assessed by the formation of dextrorphan from the CYP2D6 probe dextromethorphan (Sun et al.
Dextromethorphan DM, dextrorphan DOR, 3-methoxymorphinan 3MM, levallorphan (internal standard, IS) and [beta]-glucoronidase (Type IX-A) were purchased from Sigma Chemical Corp.
Patients who are extensive metabolizers of CYP-450 2D6 substrates show higher blood dextrorphan and increased potential to abuse dextromethorphan for its dissociative and hallucinogenic effects.
The urine volume measurements were available for all participants, and 45-mL aliquots were saved in polypropylene tubes and frozen (-20[degrees]C) until analyzed for DXT and dextrorphan (DRP).
The effects of Danshen and its active components (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on CYP2D6 activity was investigated by measuring the metabolism of a model CYP2D6 probe substrate, dextromethorphan to dextrorphan in human pooled liver microsomes.
The dextromethorphan/ dextrorphan ratio was used to classify participants as poor or extensive metabolizers (27).
The incidence of reported adverse events was higher in dosing regimens with higher peak concentrations of dextromethorphan (DM) or its metabolite product dextrorphan (DX).
Metabolism of dextromethorphan to dextrorphan (CYP2D6-mediated) and chlorzoxazone to 6-hydroxychlorzoxazone (CYP2E1-mediated) was only minimally inhibited by PSP, with [IC.
This study evaluated radioligand competitive binding for memantine, amitriptyline, fluoxetine, dextrorphan and dextromethorphan, the therapeutically active ingredient in Zenvia, to determine the binding affinities for each drug to 26 different target receptor binding sites in the brain.
Phenacetin, paracetamol, warfarin, furafylline, testosterone, 613-hydroxytestosterone, ketoconazole, 4-hydroxytolbutamide, tolbutamide, chlorzoxazone, 6-hydroxychlorzoxazone, chlorpropamide, chlorpheniramine, dextromethorphan, dextrorphan, sodium diethyl-dithiocarbamate, glucose 6-phosphate dehydrogenase (G6PDH), D-glucose 6-phosphate (G6P), [beta]-nicotinamicle adenine dinucleotide phosphate (NADP), and Tris-HCI were purchased from Sigma Chemical Co.