| Acronym | Definition |
|---|
| DISC | Discover (credit card) |
| Disc | Discount |
| DISC | Domestic International Sales Corporation |
| DISC | Discovery Channel (TV) |
| DISC | Distributed Computing (International Symposium) |
| DISC | Disconnect |
| DISC | Discontinue |
| DISC | Death-Inducing Signaling Complex (cell apoptosis) |
| DISC | Dominance/Influence/Steadiness/Conscientiousness (personality profile) |
| DISC | Defense Industrial Supply Center |
| DISC | Disconnect Command |
| DISC | Differential Scattering |
| DISC | Dynamic Information Systems Corporation |
| DISC | DNA Information and Stock Center |
| DISC | Defense Information System Council |
| DISC | Digital Information Services Center (Netherlands) |
| DISC | Discover Information Security Compliance (Discover's payment card industry data security standard compliance program) |
| DISC | Data and Information Service for CliC |
| DISC | Disaster Information Systems Clearinghouse |
| DISC | DISA Information Systems Center |
| DISC | Direct-Injection Stratified Charge engine |
| DISC | Dental Interactive Simulations Corporation |
| DISC | Development Information Services Clearinghouse (USAID) |
| DISC | Distributor Information Systems Corporation |
| DISC | Digital Information Systems Corporation |
| DISC | Data Information Service Center |
| DISC | Department of Information Systems Club (Arizona State University) |
| DISC | Digital Interchange Standard for Cardiology |
| DISC | Digital Integration Systems & Consultancy |
| DISC | Document Imaging Services Company |
| DISC | Diplomatic Intelligence Support Center |
| DISC | Data Index for Software Configuration |
| DISC | Delay In Separation Code |
| DISC | Digital International Switching Center |
| DISC | Data and Information Services for CliC (Climate and Cryosphere) |
| DISC | Design Information System Center |
| DISC | Deprivation, Immediacy, Size and Contingency (behavioral reinforcement) |
| DISC | Disarmament and International Security Committee (various organizations) |
| DISC | Dickinson Independent School District (Dickinson, TX) |