Relationship between hepatocyte necrosis, proliferation, and initiation induced by diethylnitrosamine
in the male F344 rat.
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine
in male Wistar rats.
These mice were infected with hepatitis B virus and injected with diethylnitrosamine
sixteen days after their birth.
The hepatocarcino-genicity of diethylnitrosamine
to rainbow trout and its enhancement by Aroclor-1242 and Aroclor-1254.
Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine
and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodi-benzo-p-dioxin.
TGF alpha differentially expressed in liver foci induced by diethylnitrosamine
initiation and peroxisome proliferator promotion.
Comparisons of the knockout mouse liver tumor expression profiles with those induced by ciprofibrate or diethylnitrosamine
showed that these mice shared a number of deregulated (up-or down-regulated) genes with ciprofibrate-induced liver tumors.
Studies comparing repeated dosing for early postnatal, juvenile, adult time periods, or lifetime exposures exist for six mutagens [benzidine, diethylnitrosamine
(DEN), 3-methylcholanthrene, safrole, urethane, and vinyl chloride; Tables 1, 2, 3; Supplementary Table S4 (http://ehp.
b) Benzo(a)pyrene, diethylnitrosamine
, dimethylbenzanthracene, and urethane (166 tumor incidence observations in animal groups).
This characteristic of promoters has also been demonstrated with phenobarbitol: only 20% fewer altered hepatic foci were produced when the time interval between initiation by diethylnitrosamine
and the onset of a 6-month period of promotion by phenobarbitol was increased from 1 day to 11 months (Xu et al.
0 Saline Cyclophosphamide 10 100 Saline Dexamethasone 1 10 Saline Diclofenac 10 40 Saline Diethylnitrosamine
10 100 Saline Diethylstilbestrol 2.
(DEN), and CAT on a human esophageal epithelial cell line (SNO) using the methylthiazol tetrazolium assay.