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Histologic examination of postmortem pulmonary biopsy specimen showed diffuse alveolar damage and fibrosis, real-time PCR detected enterovirus, and viral cultures were negative. Lung histology demonstrates diffuse alveolar damage superimposed on the existing fibrotic lung. Previous studies suggest that apoptosis plays a role in the pathogenesis of a diverse group of fibrosing lung diseases, including diffuse alveolar damage, idiopathic pulmonary fibrosis (Kuwano et al. |
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