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| Acronym | Definition |
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| DLE | Discoid Lupus Erythematosus | | DLE | Data Link Escape | | DLE | Dry Low Emission | | DLE | Disseminated Lupus Erythematosus (same as Systemic Lupus Erythematosus) | | DLE | Digital Local Exchange | | DLE | Didactique des Langues Étrangères (French: Teaching of Foreign Languages) | | DLE | Distance Learning Exchange (Pennsylvania Department of Education) | | DLE | Dual Language Education | | DLE | Dynamic Lightpath Establishment (IEEE) | | DLE | Department of Labor & Employment (Colorado) | | DLE | Digital Loop Electronics (Telcordia) | | DLE | Distributed LAN Emulation | | DLE | Deserts Like Eden | | DLE | Ductility Level Earthquake | | DLE | Disk List Entry (Amanda/Zmanda Backup Software) | | DLE | Double-Line Electro (stamp collecting; a form of precancellation) | | DLE | Drug Laboratory Effect | | DLE | Detailed Ledger Entry | | DLE | Development Laboratory Environment | | DLE | Diverse Learning Environments (survey) | | DLE | Direct Lightning Effects | | DLE | Department of Logistics and Engineering | | DLE | Distance Learning and Education | | DLE | Defense Liaison Element (US Army) | | DLE | Dynamic Labile Equilibrium | | DLE | Degree Level Expectations (Canada) | | DLE | Distinctive Ladies of Elegance | | DLE | Divorce Level Event | | DLE | Droits et Libertés dans les Églises (French: Rights and Liberties in the Churches) | | DLE | Datalife Engine (software) |
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