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DHFR |
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That year, a research group reported that tumor cells which resist the chemotherapeutic drug methotrexate harbor double minute chromosomes composed of many copies of the gene that encodes dihydrofolate reductase, an enzyme that deactivates the drug (SN: 1/3/87, p. Talotrexin is a novel nonpolyglutamatable antifolate drug which has demonstrated improved antitumor activity in a broad spectrum of preclinical cancer models by targeting dihydrofolate reductase (DHFR) to prevent DNA synthesis and inhibit tumor growth. One tool was based on the dihydrofolate reductase (DHFR) gene (10) and the other on the Cryptosporidium oocyst wall protein (COWP) gene (11). |
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