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DIEA |
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3 mmol) in 13 mL of anhydrous acetonitrile, diisopropylethylamine (DIEA) (5. 4] as the activator and diisopropylethylamine (DIPEA) as the base for both the initial amide bond formation and the subsequent ring closing to install the oxazoline gave the protected precursor 4. A base scan also revealed that the best outcomes were achieved with organic bases such as diisopropylethylamine (DIPEA). |
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