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References in periodicals archive ?
The company's vIgDs are developed using a process known as directed evolution, which produces proteins capable of either enhancing or diminishing an immune response and thereby may potentially apply therapeutically to cancer, autoimmune and inflammatory diseases.
Dr Ackerley and his group (currently nine students and one postdoctoral fellow) are using directed evolution to make enzymes that are more efficient at activating prodrugs.
Although the biological alterations needed to reach this goal are still highly complex (the same as those facing the intelligent designer), the scientist running a directed evolution experiment does not need to think at all about the individual gene alterations that are required.
Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis, to genome mining and high-throughput directed evolution.
Individual papers look at improving protein functions by directed evolution, chromosomal engineering strategies, monitoring and measuring the metabolome, cell-free systems for metabolic engineering, gas chromatography-mass spectroscopy for analyzing metabolic flux, natural drug discovery, alternative fuels, and other aspects.
RECENT FINDINGS: The elucidation of the crystal structure of the paraoxonase 1 (PON1) gene, obtained by directed evolution, shows that it consists of a six-bladed betapropeller with a unique active site.
1A) has proven to be a highly effective platform for various directed evolution applications, including affinity maturation (10-12) and changes in specificity (13, 14).
Diversa Corporation (San Diego, CA) has patented an invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties.
Once the scientists find this gene, they plan to use a process called directed evolution to boost the enzyme's efficiency.
Csikszentmihalyi holds that in order to engage in the task of directed evolution, we need to attain a genuine understanding of evolution itself.
The I-TRIZ Directed Evolution (DE) process provides the means to proactively control innovation and growth without relying on traditional technological forecasting.
The first 12 journals in the new initiative include Annals of General Hospital Psychiatry, Cancer Cell International, Cardiovascular Diabetology, Directed Evolution, Filarial Infections, International Journal of Equity in Health, Kineto-plastid Biology & Disease, The Malaria Journal, Microbial Cell Factories, Natural Negatives, The Nutrition Journal and Proteome Science.
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