| Acronym | Definition |
|---|
| DDD | Direct Distance Dialing |
| DDD | Digital/Digital/Digital (audio CD format, recording/mixing/mastering) |
| DDD | Division of Developmental Disabilities (various locations) |
| DDD | Degenerative Disc Disease |
| DDD | Data Display Debugger (GNU Project) |
| DDD | Domain Driven Design |
| DDD | Defined Daily Dose |
| DDD | Delta Delta Delta (sorority) |
| DDD | Dynamic Digital Depth |
| DDD | Dichlorodiphenyldichloroethane |
| DDD | Detailed Design Document |
| DDD | Drug Discovery and Development |
| DDD | Dictionary of Deities and Demons in the Bible |
| DDD | Discagem Direta À Distância (Brazilian Portuguese; direct long distance dialing) |
| DDD | Don't Drink and Drive |
| DDD | Don't Do Drugs |
| DDD | Desired Due Date |
| DDD | Drop Dead Date |
| DDD | Defense Distribution Depot |
| DDD | Deputy District Director |
| DDD | Débit de Dose (French: Dose Rate; nuclear energy) |
| DDD | Drug Distribution Data |
| DDD | Determinant Decision Diagram |
| DDD | Double Diffused Drain |
| DDD | Mayday Relay (logging abbreviation) |
| DDD | Distributed Dynamic Decisionmaking |
| DDD | Digital Diagnostic Diskette |
| DDD | Determination/Decision Document |
| DDD | Distributed Deadlock Detection |
| DDD | Documentation Driven Development (computer programming) |
| DDD | Deadline Delivery Date |
| DDD | Dat, Dicat, Dedicat (Latin: Gives, Devotes and Dedicates) |
| DDD | Desired Delivery Date |
| DDD | Design Definition Document (NASA) |
| DDD | Dooms Day Device (comics) |
| DDD | Dynamic Data Debugger |
| DDD | Display Decoder Drive |
| DDD | Delivery Due Date |
| DDD | Drug, Disease, and Drama Free |
| DDD | Detail Data Display (F-14 display console) |
| DDD | Dono Dedit Dedicavit (Latin: Gave and Dedicated as a Gift) |
| DDD | Death, Doom, and Destruction |
| DDD | Dudley Death Drop (pro wrestling) |
| DDD | Dare Devil Dive (amusement park ride) |
| DDD | Dangerous, Dirty, and Dull (robotics; tasks often given to robots) |
| DDD | DSN Data Delivery |
| DDD | Deactivation, Decontamination, Decomissioning |
| DDD | Definitely Done Deal |
| DDD | Defensive Driving Discount |
| DDD | Direction-Delay Doppler |
| DDD | Detection Discrimination Designation |
| DDD | Delivery Deadline Date |
| DDD | Dynamic Dummy Director |
| DDD | Dream it, Dare it, Do it |
| DDD | Diamond Death Drop (pro wrestling move) |
| DDD | Digital Dummy Director |
| DDD | Destination, Deliberation, Determination (Harry Potter and the Half-Blood Prince) |
| DDD | Disease Drama Drug Free (online dating) |
| DDD | Déploiements pour le Développement Démocratique (French: Deployment for Democratic Development; Canada) |
| DDD | Design Développement Durable (French: Sustainable Development Design; Belgium) |
| DDD | Deans, Directors and Department (various schools) |
| DDD | Direction du Développement Durable (French: Sustainable Development Department) |
| DDD | Drug Design and Discovery |
| DDD | Défenseur des Droits (French: Defender of Rights) |
| DDD | Discipline Determination Dedication |
| DDD | Déchets Domestiques Dangereux (French: Household Hazardous Waste; Canada) |
| DDD | Dauphine Discussion Débat (French debate association) |