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DOPAC |
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Here, for example, insult A targets the vesicular monoamine transporter in which DA is stored; insult B attacks the enzyme converting tyrosine to DOPA (3,4-dihydroxyphenylalanine) and thus the DA metabolic pathway; insult C strikes the metabolism of DOPAC (3,4-dihydroxyphenylacetic acid) to HVA (bomovanillic acid); and insult D hits the DA transporter that takes DA back up from the synaptic cleft postrelease. The supernatant solution was collected, and aliquots were used for analysis of 5HT, 5HIAA, DA, HVA, and DOPAC by HPLC with electrochemical detection (Slotkin et al. Analysis of striatal DOPAC levels in the dialysates revealed only a significant effect of sampling time [F(9,18) = 13. |
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