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E2F |
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Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR. The functions of E4 ORF 6/7 peptides of Ad7 are unknown, but the corresponding protein of adenovirus type 5 has the ability to induce the binding of cellular transcription factor E2F to the viral E2a promoter region (26). We are pursuing the development of these compounds under an alliance with Hoffmann-La Roche (Roche), which has an option to license compounds from our E2F program based on a Phase 2 clinical data package with ARQ 501 and Phase 1 data with ARQ 171. |
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