ER-PMEndoplasmic Reticulum and the Plasma Membrane
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Most available information on ER-PM contacts in cells of higher eukaryotes concerns proteins implicated in the regulation of Ca2+ entry.
2+], STIM1 forms clusters at the ER-PM junctional regions, where it physically associates with PM channels and activates SOCE.
Preventing ER-PM fusion therefore becomes an important new avenue for the treatment of infections by intracellular pathogens.