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ERCC2Excision Repair Cross-Complementing 2 (gene)
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55) Similarly we found that ERCC2 rs13181 GT and TT genotypes were significantly associated with increased risk of glioma in Chinese population with ORs(95%CI) of 1.
Conclusion: Our meta-analysis suggested that ERCC1 rs3212986 and ERCC2 rs13181 polymorphism play an important risk factor for brain tumor development in Chinese population but no association in Caucasian populations.
La existencia de polimorfismos en los genes de la enzima GSTP1 y de las enzimas de reparacion del ADN (ERCC1, ERCC2, XRCC1) que determinan una funcion o expresion alterada de las mismas y su asociacion con la respuesta al cisplatino en la que son frecuentes los eventos ototoxicos, neurotoxicos y nefrotoxicos (45), propone un desafio aun mayor en la farmacogenomica del CG; dado que la terapia combinada de 5-FU con cisplatino u oxaliplatino es utilizada en muchos paises como esquema de tratamiento de primera linea para el CG local avanzado y metastasico.
XRCC1 codon 280 and ERCC2 codon 751 polymorphisms and risk of esophageal squamous cell carcinoma in a Chinese population.
We examined genetic variants, includingsingle-nucleotide polymorphisms (SNPs) and copy-number variants (CNVs), in three genes involved in the metabolism of DBPs (GSTT1, CYP2E1, and GSTZ1), four additional genes that may play a minor role in the metabolism of DBPs (GSTT2B, GSTM1, CYP1A2, and CYP2D6), and four DNA repair genes that could be relevant when examining results, particularly for the comet assay (APEX1, ERCC2, OGG1, XRCC1).
Genotyping failed completely for the following SNPs: rs11101815 and rs915908 in CYP2E1, rsl799793 in ERCC2, and rs28903081 in the XRCC3 gene.
Influence of DNA repair gene polymorphisms of hOGGl, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.
GSTP1, ERCC1 and ERCC2 polymorphisms, expressionand clinical outcome of oxaliplatin-based adjuvantchemotherapy in colorectal cancer in Chinese population.
Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations.
Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.
Associations between XRCC1 and ERCC2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers.
Polymorphisms in the DNA repair genes XRCCl and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.