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The new compound, which is currently in preclinical trials in Japan, has a property that inhibits the activity of MAPK/ ERK kinase (MEK), a kind of enzyme involved in cell proliferation. Arsenic has been shown to activate the stress-induced kinase pathway of MAPK p38, ERK (extracellular signal-regulated kinase), and JNK (c-Jun N-terminal kinase) (Cavigelli et al. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. |
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