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ERK1/2 |
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Schermuly and colleagues (6) have previously shown that ERK1/2 was strongly suppressed by treatment with 50 mg/kg/day imatinib in rats exposed to monocrotaline, and that imatinib reversed pulmonary hypertension in this experimental model. But only inhibition of the p38 MAPK pathway significantly prevented decreasing of AIE by the various frequencies of strain, whereas the inhibition of ERK1/2 or Akt had no discernible effect on AIE (Fig. It has been shown that the immunohistochemical staining of ERK1/2 is heterogeneous, with ERK1/2 being seen mostly in the nucleus because of its transcriptional role. |
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