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For example, ESR1 was selected 99 times, 9 genes were selected more than 80 times, and 90 genes were selected more than 20 times, much more frequent than the X times expected by chance alone (Figure 3). This feature allows the encoded protein ESR1 to be used as a selectable marker of transformed cells by growing the transformed cells on cytokinin-free media. MicroRNA (miRNA)-29b Targets DNMT3A and B and Induces Re-Expression of the Hypermethylated ESR1 and p15 Genes in Acute Myeloid Leukemia (AML) |
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