In diabetic animal models, EGCG
delayed the onset of type 1 diabetes in spontaneous non-obese mice, reduced the increase of blood glucose levels and ameliorated the decrease of islet mass induced by low-doses of streptozotocin (24,25), and ameliorated vascular reactivity in rats and enhanced glucose tolerance in rodents (26,27).
The findings revealed the mice eating HFFD plus EGCG
were less likely to gain more weight and experience insulin resistance in response to a HFFD.
Green tea--and especially the EGCG
contained in green tea extracts--powerfully fights many of the causes and consequences of diabesity.
is believed to work by inhibiting the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) enzyme, which is overexpressed in people with Down syndrome and which appears to play a role in the pathogenesis of intellectual deficits in these individuals.
The cancer preventive and inhibitory effects of EGCG
have been extensively demonstrated in different tumor cell lines and animal models, and its mechanisms are involved in cell cycle arrest, apoptosis, angiogenesis, and anti-oxidant activity.
There are many studies regarding the use of EGCG
in medicine, however few and recent studies have been conducted on the use of EGCG
in Dentistry, since this substance is found in a very popular drink that contacts the oral mucosa, it may have antimicrobial efficacy and play an anticariogenic role.
Methods: In vitro effects of EGCG
on the transcription, translation, or degradation of [beta]-catenin were investigated.
Group 1 served as control and groups 2, 3, and 4 were treated with TQ (16 [micro]M), EGCG
(3 [micro]g/ml), and TQ + EGCG
is a water soluble polyphenol and the problem with water soluble polyphenols is that they have difficulty crossing the lipid friendly cell membranes in the intestine.
Therefore, we performed the present study to evaluate the effect of EGCG
on the kidney function in db/db mice.
([greater than or equal to] 95%) was purchased from Sigma-Aldrich, St.
The aim of this study was to determine the potential of the prepared porous materials to adsorb, separate, and purify EGCG