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EGR1Early Growth Response 1
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Abbott also recently received FDA clearance for the Vysis EGR1 FISH Probe Kit to aid in determining the prognosis of patients with acute myeloid leukemia.
5] Human genes: F3, coagulation factor III (thromboplastin, tissue factor); KRAS, v-KI-ras 2 Kirsten rat sarcoma viral oncogene homolog; TP53, tumor protein p53; PTEN, phosphatase and tensin homolog; STK11, serine/threonine kinase 11; HPSE, heparanase; EGR1, early growth response 1; EGFR, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian).
Downstream targets of CD95 essential for cell growth, such as JNK, c-Fos and Egr1, also decreased their activity when the 'death receptor' was blocked.
Repression of MYC and the early growth-response gene EGR1 in this group may further negatively regulate E2F1 and its target gene expression.
Abbott's Vysis EGR1 FISH Probe Kit, the third Abbott FISH assay approved or cleared in the past two months by the FDA for oncology applications, detects a chromosomal deletion in bone marrow that is usually associated with an unfavorable prognosis for AML patients.
CM samples collected from cultures of glucose-responsive MIN6(L) cells and glucose-nonresponsive MIN6(H) cells were analyzed for several transcripts, including those for Pld1, Egr1, Chgb, and Ins1 (Fig.
The search identified potential binding sites for C2H2 zinc finger proteins, such as the specificity protein (SP) family and Egr1 at -51delA and SREBP at -1023C>A.