| Acronym | Definition |
|---|
| ESB | Enterprise Service Bus |
| ESB | Empire State Building (New York City, NY, USA) |
| ESB | Electricity Supply Board (Ireland) |
| ESB | Empire Strikes Back |
| ESB | Extra Special Bitter |
| ESB | The Empire Strikes Back |
| ESB | European School of Business (Reutlingen, Germany) |
| ESB | Engineer Support Battalion |
| ESB | European Society of Biomechanics |
| ESB | E-Street Band (Bruce Springsteen's band) |
| ESB | École Supérieure du Bois (French wood processing school) |
| ESB | English Speaking Board (UK) |
| ESB | Erdgas Südbayern GmbH (natural gas utility; Munich, Germany) |
| ESB | Encefalopatía Spongiforme Bovina (Spanish: Bovine Spongiform Encephalopathy) |
| ESB | Expeditionary Signal Battalion (US DoD) |
| ESB | Engrossed Senate Bill |
| ESB | Extra Strong Bitter (beer) |
| ESB | Economic Services Bureau (Hong Kong) |
| ESB | Enhanced Separate Brigade |
| ESB | Engineering Society of Baltimore |
| eSB | Enhanced Separate Brigade (UA Army) |
| ESB | Ankara, Turkey - Esenboga (Airport Code) |
| ESB | Emergency Service Bureau |
| ESB | Embedded System Block |
| ESB | Eastern Savings Bank |
| ESB | Emergency Services Branch |
| ESB | Engineering Society of Buffalo |
| ESB | Energy Star Buildings |
| ESB | Environmental Services Branch (US EPA) |
| ESB | Effective Sample Base |
| ESB | Embedded Single Board |
| ESB | Executive Steering Board |
| ESB | Encéphalopathie Spongioforme Bovine |
| ESB | Environmental Stewardship Branch |
| ESB | Etiology and Surveillance Branch (ASPH) |
| ESB | Esterase B |
| ESB | Electrical Substitution Bolometer |
| ESB | En Route Support Base |
| ESB | Elastic Storage Buffer |
| ESB | Exhaust Stack Blocker (non-lethal weapon) |
| ESB | Echostrong Band (ultrasound) |
| ESB | Embotelladora San Bernardino (Guatemala) |
| ESB | East San Bruno |
| ESB | Emergency Stow Bypass |
| ESB | Emergency Switch Board (electrical; marine) |
| ESB | English Sports Betting (UK) |
| ESB | Edwards School of Business (Canada) |
| ESB | Erste & Steiermärkische Bank (Bosnia and Herzegovina) |
| ESB | European Schools Brussels (Brussels, Belgium swim team) |
| ESB | Engineering Sciences Building (various schools) |
| ESB | External Security Bulletin (Australian Computer Emergency Response Team) |
| ESB | East Side Boyz (band) |