| Acronym | Definition |
|---|
| ESE | Exceptional Student Education (Florida) |
| ESE | Erasmus School of Economics (Erasmus University Rotterdam; Netherlands) |
| ESE | Extensible Storage Engine (Microsoft Exchange Server) |
| ESE | Environmental Science and Engineering |
| ESE | Exonic Splicing Enhancer |
| ESE | École Supérieure d'Electricité (French electrical school) |
| ESE | Entrance Skin Exposure (medical x-ray) |
| ESE | Enterasys Systems Engineer |
| ESE | Experimental School Environment |
| ESE | Expert Systems Environment |
| ESE | Exceptional/Special Education |
| ESE | Electronic Surveillance Enhancement |
| ESE | Escola de Sargentos do Exército (Portugal) |
| ESE | Equipment Service Employee (airline employee) |
| ESE | Enhanced Secure Environment (anti-cheat gaming software) |
| ESE | EVA Support Equipment |
| ESE | Engineer Support Equipment (Army) |
| ESE | Electronic Security Europe |
| ESE | Exact Signed English |
| ESE | External Speed Expansion |
| ESE | Enhanced Spectrum Efficiency |
| ESE | European Society of Endontology |
| ESE | Eastern States Exposition (West Springfield, MA) |
| ESE | Easy Serving Espresso |
| ESE | Empirical Software Engineering |
| ESE | Eclipse Summit Europe |
| ESE | Early Streamer Emitter (ligthning protection) |
| ESE | Earth Science Enterprise (NASA) |
| ESE | East-South-East |
| ESE | Electronic Security Equipment |
| ESE | Elementary and Secondary Education (various locations) |
| ESE | Enterprise Systems Engineering |