| Acronym | Definition |
|---|
| Esc | Escape (character or keyboard key) |
| ESC | European Society of Cardiology |
| ESC | Electronic Stability Control |
| ESC | Eurovision Song Contest |
| ESC | Education Service Center |
| ESC | Embedded Systems Conference |
| ESC | Embryonic Stem Cell |
| ESC | École Supérieure de Commerce (French) |
| ESC | EISA (Extended Industry Standard Architecture) System Component |
| ESC | Escudo (Portuguese currency) |
| ESC | Empire State College (New York) |
| ESC | Economic and Social Committee (EU) |
| ESC | Electronic Systems Center |
| ESC | Electronic Speed Control (DC motor) |
| ESC | Escalator |
| ESC | Employment Security Commission |
| ESC | Erosion and Sediment Control |
| ESC | European Shippers' Council |
| ESC | Essential Services Commission (Australia) |
| ESC | Educational Software Cooperative |
| ESC | Economic and Social Council |
| ESC | European Social Charter |
| ESC | Executive Steering Committee |
| ESC | Electronic Still Camera |
| ESC | Equitable Stroke Control (golf scoring modifier) |
| ESC | Evergreen State College (Washington) |
| ESC | Engineering Student Council |
| ESC | Equine Science Center |
| ESC | European Seismological Commission |
| ESC | European Stroke Conference |
| ESC | European Society of Contraception |
| ESC | Extended Static Checking |
| ESC | Environmental Systems Corporation |
| ESC | Energy Services Coalition |
| ESC | English-Speaking Countries |
| ESC | Electronic Service Center |
| ESC | Environmental Stress Cracking |
| ESC | Entomological Society of Canada |
| ESC | European Society of Criminology |
| ESC | Environmental Support Center |
| ESC | Electronic Spark Control |
| ESC | East Surrey College (UK) |
| ESC | Escuintla (Guatemala territorial division) |
| ESC | Eastern Snow Conference |
| ESC | Electronic Supply Chain |
| ESC | Environmental Science Center |
| ESC | Escadas (Portuguese: stairs; postal usage) |
| ESC | Eurobodalla Shire Council (Australia) |
| ESC | Endangered Species Coalition (Washington, DC) |
| ESC | European Shooting Confederation |
| ESC | Employee Service Center |
| ESC | European Studies Consortium |
| ESC | Electronic Security Command |
| ESC | Evergreen Safety Council |
| ESC | European Students' Conference |
| ESC | Every Second Counts |
| ESC | Expeditionary Sustainment Command (Army Modular Logistics unit) |
| ESC | Egyptian Satellite Channel |
| ESC | Energy Solutions Center |
| ESC | Environmental Steering Committee |
| ESC | English School of Canada (Toronto, Canada) |
| ESC | Ecole des Sciences Criminelles |
| ESC | Entertainment Software Charity |
| ESC | Email Security Conference |
| ESC | Endangered Species Committee |
| ESC | Educational Services Commission |
| ESC | English-Speaking Caribbean |
| ESC | English Sports Council (UK) |
| ESC | Engineering Support Center |
| ESC | European Support Centre |
| ESC | Ethnic Student Center |
| ESC | Enterprise Security Client |
| ESC | Export Service Center |
| ESC | Extra-Statutory Concessions |
| ESC | Executive Steering Council |
| ESC | Endometrial Stromal Cell |
| ESC | Express Service Code |
| ESC | Edmond Soccer Club (Edmond, OK, USA) |
| ESC | Executive Service Corps of Washington |
| ESC | European Simulation Congress |
| ESC | Executive Support Center (Pentagon command center) |
| ESC | Employment Studies Centre (Australia) |
| ESC | Engineering Service Circuit |
| ESC | Escanaba, MI, USA - Delta County Airport (Airport Code) |
| ESC | Eldorado Sport Coupe (Cadillac automobile) |
| ESC | Electrical Safety Committee |
| ESC | Eindhovens Studenten Corps (Netherlands) |
| ESC | Environmental Sustainability Committee |
| ESC | European Space Conference |
| ESC | Electrical Systems Consultants, Inc. |
| ESC | Education Standards Commission |
| ESC | Elementary Concepts in Statistics |
| ESC | Earth Simulation Center |
| ESC | Economic Security Corporation |
| ESC | Engineering Science Courses |
| ESC | Economics of Software and Computation |
| ESC | European Studies Conference |
| ESC | Energy Systems Centre (Australia) |
| ESC | Earth Science Centre |
| ESC | Employment Status Code |
| ESC | Erdos-Strauss Conjecture |
| ESC | Environment Stress Cracking |
| ESC | Expert Systems Consulting |
| ESC | Enhanced Speech Circuit |
| ESC | Equipment Serviceability Criteria |
| ESC | Eagle Ski Club (UK) |
| ESC | Entertainment Service Center (wireless entertainment software) |
| ESC | Evaluation Services Center |
| ESC | European Standardisation Committee |
| ESC | Endogenous Sunk Costs |
| ESC | European Stevia Center |
| ESC | Economics Society of Calgary (Alberta, Canada) |
| ESC | Evaporative Spray Cooling |
| ESC | Enhanced Satellite Capability |
| ESC | Egypt Study Circle (philatelic research group) |
| ESC | Executive and Supervisory Committee |
| ESC | Expert Service Center |
| ESC | Electronic System Command |
| ESC | Engineering Systems and Computing |
| ESC | Essex Scooby Crew (Subaru Car club based in Essex) |
| ESC | Environmental Safety Center |
| ESC | Enterics-STD-Chromatography |
| ESC | Environmental System Controller |
| ESC | East Side Connection (gaming clan) |
| ESC | Electrostatic Deflector |
| ESC | Extra Scan Chain |
| ESC | Extended Synchronizing Codeword |
| ESC | Extended Spectrum Capacity |
| ESC | Enterprise Standard Cost |
| ESC | Elected Staff Council |
| ESC | Executive Seminar Center |
| ESC | Estes Satellite & Communications, Inc. |
| ESC | East Side Clique |
| ESC | Engineering Semiconductor Courses |
| ESC | Electrical Systems Center |
| ESC | Endangered Species Commission |
| ESC | Essentiality/Criticality/Sensitivity (security) |
| ESC | Engineering Service Contractor |
| ESC | Environmental Sustainability Workshop |
| ESC | Electronic Student Companion |
| ESC | ELINT Subsystem Computer |
| ESC | Employed Site Commander |
| ESC | Electro-Static Clamp |
| ESC | Equipment Structure Code |
| ESC | Enemy Situation Capabilities |
| ESC | Environmental Studies Contract |
| ESC | Enhanced Service Connection |
| ESC | Enemy Situation Components |
| ESC | Equipment Status Chart |
| ESC | Equal Status Council in Norway (women's policy agency) |
| ESC | Electrical Service Center |